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Cyclization of the Antimicrobial Peptide Gomesin with Native Chemical Ligation
Cyclization of the Antimicrobial Peptide Gomesin with Native Chemical Ligation: Influences on Stability and Bioactivity. Chan LY, Zhang VM, Huang YH, Waters NC, Bansal PS, Craik DJ, Daly NL. Chembiochem. 2013 Feb 20. doi: 10.1002/cbic.201300034. [Epub ahead of print]...
Fmoc-based peptide thioester synthesis with self-purifying effect: heading to native chemical ligation in parallel formats
Fmoc-based peptide thioester synthesis with self-purifying effect: heading to native chemical ligation in parallel formats Franziska Thomas, J. Pept. Sci., 2013, 19, 141–147 DOI: 10.1002/psc.2494, Copyright © 2013 European Peptide Society and John Wiley & Sons,...
Medusins: A new class of antimicrobial peptides from the skin secretions of phyllomedusine frogs
Medusins: A new class of antimicrobial peptides from the skin secretions of phyllomedusine frogs Xinping Xi, Renjie Li, Yingchun Jiang, Yan Lin, Yuxin Wu, Mei Zhou, Jie Xu, Lei Wang, , Tianbao Chen, Chris Shaw, Biochimie, Available online 14 February 2013 doi:...
Design of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus
Design of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus Wei Hong, Runhong Zhang, Zhiyong Di, Yawen He, Zhenhuan Zhao, Jun Hu, Yingliang Wu, Wenxin Li, Zhijian Cao, Biomaterials, Available online 13 February...
IbACP, a Sixteen-Amino-Acid Peptide Isolated from Ipomoea batatas Leaves, Induces Carcinoma Cell Apoptosis
IbACP, a Sixteen-Amino-Acid Peptide Isolated from Ipomoea batatas Leaves, Induces Carcinoma Cell Apoptosis Vincent H.-S. Chang, Diane H.-A. Yang, Hsin-Hung Lin, Gregory Pearce, Clarence A. Ryan, Yu-Chi Chen, Peptides, Available online 18 February 2013...
A concise preparation of the fluorescent amino acid l-(7-hydroxycoumarin-4-yl) ethylglycine and extension of its utility in solid phase peptide synthesis
A concise preparation of the fluorescent amino acid l-(7-hydroxycoumarin-4-yl) ethylglycine and extension of its utility in solid phase peptide synthesis Timo Koopmans, Matthijs van Haren, Linda Quarles van Ufford, Jeffrey M. Beekman, Nathaniel I. Martin Bioorg. Med....
Concise Synthetic Routes to Human Insulin
Concise Synthetic Routes to Human Insulin Fa Liu, Ethan Y. Luo, David B. Flora, and John P. Mayer Org. Lett., 2013, 15 (4), pp 960–963 DOI: 10.1021/ol400149j Publication Date (Web): February 7, 2013 Copyright © 2013 American Chemical Society We report a set of...
Effect of cationic cyclopeptides on transdermal and transmembrane delivery of insulin
Effect of cationic cyclopeptides on transdermal and transmembrane delivery of insulin Mingming Chang , Xiaohui Li , Yuming Sun , Fang Cheng , Qing Wang , Xiaohuan Xie , Weijie Zhao , and Xin Tian Mol. Pharmaceutics, Just Accepted Manuscript DOI: 10.1021/mp300667p...
Amino Acid Building Blocks for Fmoc Solid-Phase Synthesis of Peptides Phosphocholinated at Serine, Threonine, and Tyrosine
Amino Acid Building Blocks for Fmoc Solid-Phase Synthesis of Peptides Phosphocholinated at Serine, Threonine, and Tyrosine Michael F. Albers and Christian Hedberg J. Org. Chem., Article ASAP DOI: 10.1021/jo302587g Publication Date (Web): February 1, 2013 Copyright ©...
Cleavage and Final Deprotection with Dilute HCl in Fluoro Alcohol
New TFA-Free Cleavage and Final Deprotection in Fmoc Solid-Phase Peptide Synthesis: Dilute HCl in Fluoro Alcohol P. Palladino and D. A. Stetsenko, Org. Lett., Article ASAP DOI: 10.1021/ol303124r Publication Date (Web): December 4, 2012 Copyright © 2012 American...
Peptide Scanning for Studying Structure-Activity Relationships in Drug Discovery
Peptide Scanning for Studying Structure-Activity Relationships in Drug Discovery Andrew G. Jamieson, Nicolas Boutard, David Sabatino, William D. Lubell Chem Biol. Drug Design, 2013, 81, 148–165. DOI: 10.1111/cbdd.12042 Peptide-based therapeutics have grown in...
N-Methylation of Peptides and Proteins: An Important Element for Modulating Biological Functions
N-Methylation of Peptides and Proteins: An Important Element for Modulating Biological Functions Jayanta Chatterjee, Florian Rechenmacher, Horst Kessler Angew. Chem. Int. Ed. 2013, 52, 254–269. DOI: 10.1002/anie.201205674 N-Methylation is one of the simplest...
Prospects in the Total Synthesis of Protein Therapeutics
Prospects in the Total Synthesis of Protein Therapeutics Justin M. Chalker Chem. Biol. Drug Design, 2013, 81, 122–135 DOI: 10.1111/cbdd.12007 Protein therapeutics are gaining headway in the treatment and prevention of a variety of maladies. Critical to the success...
The Future of Peptide-based Drugs
The Future of Peptide-based Drugs David J. Craik, David P. Fairlie, Spiros Liras, David Price Chem. Biol. Drug Design, 2013, 81, 136–147. DOI: 10.1111/cbdd.12055 The suite of currently used drugs can be divided into two categories – traditional ‘small...
Antimicrobial peptides from scorpion venom
A novel class of antimicrobial peptides from the scorpion Heterometrus spinifer. Nie Y, Zeng XC, Yang Y, Luo F, Luo X, Wu S, Zhang L, Zhou J. Peptides. 2012, 38, 389-94. doi: 10.1016/j.peptides.2012.09.012. The venom peptides from the scorpion Heterometrus spinifer...
Gene delivery using peptide carriers
Rapid and efficient gene delivery into plant cells using designed peptide carriers. Manoj Kumar Lakshmanan , Yutaka Kodama , Takeshi Yoshizumi , Kumar Sudesh , and Keiji Numata Biomacromolecules, Just Accepted Manuscript DOI: 10.1021/bm301275g Publication Date (Web):...
Antibacterial and leishmanicidal activities of temporin-SHd
Antibacterial and leishmanicidal activities of temporin-SHd, a 17-residue long membrane-damaging peptide. Abbassi F, Raja Z, Oury B, Gazanion E, Piesse C, Sereno D, Nicolas P, Foulon T, Ladram A., Biochimie. 2012 Oct 29. doi: 10.1016/j.biochi.2012.10.015. [Epub ahead...
Retro-Inverso Version of Catestatin Shows Prolonged Efficacy in Mouse Model of Hypertension
Novel Peptide Isomer Strategy for Stable Inhibition of Catecholamine Release: Application to Hypertension. Biswas N, Gayen J, Mahata M, Su Y, Mahata SK, O'Connor DT., Hypertension. 2012, 60(6), 1552-1559. doi: 10.1161/HYPERTENSIONAHA.112.202127 Epub 2012 Nov 5....
