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Native Chemical Ligation-Thiolene Click (NCL-TEC)

Native Chemical Ligation-Thiolene Click (NCL-TEC): A Methodology for the Synthesis of Functionalized Peptides. L. Markey, S. Giordani, E.M. Scanlan, J Org Chem. 2013 Apr 8. [Epub ahead of print] DOI: 10.1021/jo4001542 The sequential combination of native chemical...

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Synthesis of new vasotocin analogues

Synthesis of new vasotocin analogues: effects on renal water and ion excretion in rats. A.V. Kutina, A.S. Marina, I.I. Eliseev, M.I. Titov, Y.V. Natochin, J Pept Sci. 2013 Mar 27. [Epub ahead of print] DOI: 10.1002/psc.2495 Vasopressin and nonmammalian hormone...

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New cyclic dermorphin/deltorphin analogues

Synthesis, biological activity and resistance to proteolytic digestion of new cyclic dermorphin/deltorphin analogues K. BaÅ„kowski, E. Witkowska, O. M. Michalak, K.  Sidoryk, E. Szymanek, B. Antkowiak, M. Paluch, K.E. Filip, M. Cebrat, B. Setner, Z. Szewczuk, P....

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3-Hydroxyazetidine Carboxylic Acids

3-Hydroxyazetidine carboxylic acids: non-proteinogenic amino acids for medicinal chemists. AF Glawar, SF Jenkinson, AL Thompson, S. Nakagawa, A. Kato, TD Butters, GW Fleet, ChemMedChem. 2013, 8, 658-66. DOI: 10.1002/cmdc.201200541. Epub 2013 Mar 6. The formation from...

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Bioinspired Self-Assembled Peptide Nanofibers

Bioinspired Self-Assembled Peptide Nanofibers with Thermostable Multivalent α-Helices S.-h. Han, M.-k. Lee,  Y.-b. Lim, Biomacromolecules, Article ASAP DOI: 10.1021/bm400233x Publication Date (Web): April 3, 2013 Copyright © 2013 American Chemical Society The...

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Synthesis and Use of Fmoc-Lys(5-Fam)-OH

The synthesis and application of Fmoc-Lys(5-Fam) building blocks. Tokmina-Roszyk M, Tokmina-Roszyk D, Fields GB. Biopolymers. 2013 Feb 26. doi: 10.1002/bip.22222. [Epub ahead of print] Fluorescence resonance energy transfer (FRET) peptide substrates are often utilized...

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Preparation of C-terminal Peptide Thiolesters

A comparison of Boc and Fmoc SPPS strategies for the preparation of C-terminal peptide α-thiolesters: NY-ESO-1 (39) Cys-(68) Ala-COSR. Harris PW, Brimble MA., Biopolymers. 2013 Feb 26. doi: 10.1002/bip.22223. [Epub ahead of print] The synthesis of a polypeptide...

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Alanine Scan of Peptide Antibiotic Feglymycin

Alanine Scan of the Peptide Antibiotic Feglymycin: Assessment of Amino Acid Side Chains Contributing to Antimicrobial Activity. Hänchen A, Rausch S, Landmann B, Toti L, Nusser A, Süssmuth RD. Chembiochem., 2013, 14, 625-32. DOI: 10.1002/cbic.201300032. The...

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New Arginine Vasopressin Analogs

Design, Synthesis and Structure–Activity Relationship of New Arginine Vasopressin Analogues Containing Proline Derivatives in Position 2 A Kwiatkowska, M Lewandowska, L Borovičková, J Slaninová, B Lammek, A Prahl, Chem. Biol. Drug Design, 2013, 81, 420–428....

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Boc-Oxyma as Racemization-Free Coupling Reagent

Ethyl 2-(tert-Butoxycarbonyloxyimino)-2-cyanoacetate (Boc-Oxyma) as Coupling Reagent for Racemization-Free Esterification, Thioesterification, Amidation and Peptide Synthesis K Thalluri, KC Nadimpally, MP Chakravarty, A Paul, B Mandal, Advan. Synth. Catal., 2013, 355,...

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