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Synthesis and Evaluation of Novel Cyclic Peptide Inhibitors of Lysine-Specific Demethylase 1
Synthesis and Evaluation of Novel Cyclic Peptide Inhibitors of Lysine-Specific Demethylase 1 Isuru R. Kumarasinghe and Patrick M. Woster, ACS Med. Chem. Lett., 2013, Just Accepted Manuscript, DOI: 10.1021/ml4002997 Publication Date (Web): November 8, 2013 ...
Methanobactin-mediated one-step synthesis of gold nanoparticles.
Methanobactin-mediated one-step synthesis of gold nanoparticles. Xin JY, Cheng DD, Zhang LX, Lin K, Fan HC, Wang Y, Xia CG. Int J Mol Sci., 2013, 14, 21676-88. doi: 10.3390/ijms141121676. Preparation of gold nanoparticles with a narrow size distribution has enormous...
A Synthetic Peptide to Control Rice Blast Disease
PAF104, a Synthetic Peptide to Control Rice Blast Disease by Blocking Appressorium Formation in Magnaporthe oryzae. Rebollar A, López-GarcÃa B., Mol Plant Microbe Interact. 2013, 26, 1407-16. doi: 10.1094/MPMI-04-13-0110-R. Magnaporthe oryzae is the most devastating...
Modular assembly of dimeric HIV fusion inhibitor peptides with enhanced antiviral potency.
Modular assembly of dimeric HIV fusion inhibitor peptides with enhanced antiviral potency. Xiao J, Tolbert TJ., Bioorg Med Chem Lett., 2013, 23, 6046-51. doi: 10.1016/j.bmcl.2013.09.034. Epub 2013 Sep 20. The HIV-1 envelope gp120/gp41 glycoprotein...
Synthetic analogues of bovine bactenecin dodecapeptide reduce herpes simplex virus type 2 infectivity in mice.
Synthetic analogues of bovine bactenecin dodecapeptide reduce herpes simplex virus type 2 infectivity in mice. Shestakov A, Jenssen H, Hancock RE, Nordström I, Eriksson K. Antiviral Res., 2013, 100, 455-9. ...
Antimicrobial peptide Epinecidin-1 effective against MRSA infection in mice
Use of the antimicrobial peptide Epinecidin-1 to protect against MRSA infection in mice with skin injuries. Huang HN, Rajanbabu V, Pan CY, Chan YL, Wu CJ, Chen JY., Biomaterials., 2013, 34, 10319-27. doi:...
Short Analogs from Human Cathelicidin LL-37 Possess Antimicrobial and Antiendotoxic Activities
Short KR-12 analogs designed from human cathelicidin LL-37 possessing both antimicrobial and antiendotoxic activities without mammalian cell toxicity. Jacob B, Park IS, Bang JK, Shin SY., J Pept Sci., 2013, 19, 700-7. doi: 10.1002/psc.2552. KR-12 (residues...
Anti-bacterial Peptide has Potental in Anti-fungal Treatment
C. albicans growth, transition, biofilm formation, and gene expression modulation by antimicrobial decapeptide KSL-W. Theberge S, Semlali A, Alamri A, Leung KP, Rouabhia M., BMC Microbiol. 2013, 13, 246. Antimicrobial peptides have been the focus of much research over...
Novel α-Conotoxin that Potently Blocks α3β4 Nicotinic Acetylcholine Receptors
Characterization of a Novel α-Conotoxin TxIC from Conus textile that Potently Blocks rat α3β4 Nicotinic Acetylcholine Receptors Sulan Luo , Dongting Zhangsun , Xiaopeng Zhu , Yong Wu , Yuanyan Hu , Sean Christensen , Peta J. Harvey , Muharrem Akcan , David J Craik...
Minimum active structure of insulin-like peptide 5 (INSL5)
Minimum active structure of insulin-like peptide 5 (INSL5) Alessia Belgi , Ross A.D. Bathgate , Martina Kocan , Nitin Patil , Suode Zhang , Geoffrey W Tregear , John D. Wade , and Mohammed Akhter Hossain, J. Med. Chem., Just Accepted Manuscript DOI: 10.1021/jm400924p...
A Short Tryptophan-Rich Cationic Antimicrobial Peptide
Dynamic Turn Conformation of a Short Tryptophan-Rich Cationic Antimicrobial Peptide and its Interaction with Phospholipid Membranes Matthew Nichols , Miljan Kuljanin , Mostafa Nategholeslam , Tuan Hoang , Shaghayegh Vafaei , Bruno Tomberli , Chris G Gray , Lillian...
New Soluble Resin for Peptide Synthesis
Soluble and Reusable Poly(norbornene) Supports with High Loading Capacities for Peptide Synthesis Nimmashetti Naganna and Nandita Madhavan * Org. Lett., 2013, 15, 5870-5873. DOI: 10.1021/ol4029435 Copyright © 2013 American Chemical Society Poly(norbornene) supports...
Enantioselective Synthesis of 2-Substitued-Tetrahydroisoquinolin-1-yl Glycine Derivatives
Enantioselective Synthesis of 2-Substitued-Tetrahydroisoquinolin-1-yl Glycine Derivatives via Oxidative Cross-Dehydrogenative Coupling of Tertiary Amines and Chiral Nickel(II) Glycinate Shengbin Zhou , Jiang Wang , Daizong Lin , Fei Zhao , and Hong Liu J. Org. Chem.,...
Bis(2-sulfanylethyl)amido Peptides Enable Native Chemical Ligation at Proline
Bis(2-sulfanylethyl)amido Peptides Enable Native Chemical Ligation at Proline and Minimize Deletion Side-Product Formation Laurent Raibaut , Phillip Seeberger , and Oleg Melnyk * Org. Lett., Article ASAP DOI: 10.1021/ol402678a Publication Date (Web): October 11, 2013...
Effective synthesis of kynurenine-containing peptides
Effective synthesis of kynurenine-containing peptides via on-resin ozonolysis of tryptophan residues: synthesis of cyclomontanin B. Wong CT, Lam HY, Li X., Org Biomol Chem. 2013, 11, 7616-20. The preparation of Kyn-containing peptides is difficult, owing to the low...
Implications of Angiotensin II in Central Nervous System on Exercise Performance.
Implications of Angiotensin II in Central Nervous System on Exercise Performance. Leite LH, Santiago HP, de Almeida RS, Coimbra CC. Curr Protein Pept Sci. 2013 Oct 4. [Epub ahead of print] The renin-angiotensin system (RAS) consists of a complex enzyme-peptide system,...
A Novel Aliphatic Tachykinin from the Skin Secretion of the Chinese Brown Frog, Rana chensinensis.
Ranachensinin: A Novel Aliphatic Tachykinin from the Skin Secretion of the Chinese Brown Frog, Rana chensinensis. Wu Y, Li R, Ma J, Zhou M, Wang L, McClure TI, Cai J, Chen T, Shaw C. Protein Pept Lett. 2013, 20, 1217-1224. Amphibian skin secretions contain a plethora...
Antifungal effect of lactoferricin B like peptide derived from centipede
Antifungal effect and pore-forming action of lactoferricin B like peptide derived from centipede Scolopendra subspinipes mutilans. Choi H, Hwang JS, Lee DG. Biochim Biophys Acta. 2013, 1828, 2745-2750. doi: 10.1016/j.bbamem.2013.07.021. Epub 2013 Jul 26. The centipede...
