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Antimicrobial peptide Epinecidin-1 effective against MRSA infection in mice
Use of the antimicrobial peptide Epinecidin-1 to protect against MRSA infection in mice with skin injuries. Huang HN, Rajanbabu V, Pan CY, Chan YL, Wu CJ, Chen JY., Biomaterials., 2013, 34, 10319-27. doi:...
Short Analogs from Human Cathelicidin LL-37 Possess Antimicrobial and Antiendotoxic Activities
Short KR-12 analogs designed from human cathelicidin LL-37 possessing both antimicrobial and antiendotoxic activities without mammalian cell toxicity. Jacob B, Park IS, Bang JK, Shin SY., J Pept Sci., 2013, 19, 700-7. doi: 10.1002/psc.2552. KR-12 (residues...
Anti-bacterial Peptide has Potental in Anti-fungal Treatment
C. albicans growth, transition, biofilm formation, and gene expression modulation by antimicrobial decapeptide KSL-W. Theberge S, Semlali A, Alamri A, Leung KP, Rouabhia M., BMC Microbiol. 2013, 13, 246. Antimicrobial peptides have been the focus of much research over...
Novel α-Conotoxin that Potently Blocks α3β4 Nicotinic Acetylcholine Receptors
Characterization of a Novel α-Conotoxin TxIC from Conus textile that Potently Blocks rat α3β4 Nicotinic Acetylcholine Receptors Sulan Luo , Dongting Zhangsun , Xiaopeng Zhu , Yong Wu , Yuanyan Hu , Sean Christensen , Peta J. Harvey , Muharrem Akcan , David J Craik...
Minimum active structure of insulin-like peptide 5 (INSL5)
Minimum active structure of insulin-like peptide 5 (INSL5) Alessia Belgi , Ross A.D. Bathgate , Martina Kocan , Nitin Patil , Suode Zhang , Geoffrey W Tregear , John D. Wade , and Mohammed Akhter Hossain, J. Med. Chem., Just Accepted Manuscript DOI: 10.1021/jm400924p...
A Short Tryptophan-Rich Cationic Antimicrobial Peptide
Dynamic Turn Conformation of a Short Tryptophan-Rich Cationic Antimicrobial Peptide and its Interaction with Phospholipid Membranes Matthew Nichols , Miljan Kuljanin , Mostafa Nategholeslam , Tuan Hoang , Shaghayegh Vafaei , Bruno Tomberli , Chris G Gray , Lillian...
New Soluble Resin for Peptide Synthesis
Soluble and Reusable Poly(norbornene) Supports with High Loading Capacities for Peptide Synthesis Nimmashetti Naganna and Nandita Madhavan * Org. Lett., 2013, 15, 5870-5873. DOI: 10.1021/ol4029435 Copyright © 2013 American Chemical Society Poly(norbornene) supports...
Enantioselective Synthesis of 2-Substitued-Tetrahydroisoquinolin-1-yl Glycine Derivatives
Enantioselective Synthesis of 2-Substitued-Tetrahydroisoquinolin-1-yl Glycine Derivatives via Oxidative Cross-Dehydrogenative Coupling of Tertiary Amines and Chiral Nickel(II) Glycinate Shengbin Zhou , Jiang Wang , Daizong Lin , Fei Zhao , and Hong Liu J. Org. Chem.,...
Bis(2-sulfanylethyl)amido Peptides Enable Native Chemical Ligation at Proline
Bis(2-sulfanylethyl)amido Peptides Enable Native Chemical Ligation at Proline and Minimize Deletion Side-Product Formation Laurent Raibaut , Phillip Seeberger , and Oleg Melnyk * Org. Lett., Article ASAP DOI: 10.1021/ol402678a Publication Date (Web): October 11, 2013...
Effective synthesis of kynurenine-containing peptides
Effective synthesis of kynurenine-containing peptides via on-resin ozonolysis of tryptophan residues: synthesis of cyclomontanin B. Wong CT, Lam HY, Li X., Org Biomol Chem. 2013, 11, 7616-20. The preparation of Kyn-containing peptides is difficult, owing to the low...
Implications of Angiotensin II in Central Nervous System on Exercise Performance.
Implications of Angiotensin II in Central Nervous System on Exercise Performance. Leite LH, Santiago HP, de Almeida RS, Coimbra CC. Curr Protein Pept Sci. 2013 Oct 4. [Epub ahead of print] The renin-angiotensin system (RAS) consists of a complex enzyme-peptide system,...
A Novel Aliphatic Tachykinin from the Skin Secretion of the Chinese Brown Frog, Rana chensinensis.
Ranachensinin: A Novel Aliphatic Tachykinin from the Skin Secretion of the Chinese Brown Frog, Rana chensinensis. Wu Y, Li R, Ma J, Zhou M, Wang L, McClure TI, Cai J, Chen T, Shaw C. Protein Pept Lett. 2013, 20, 1217-1224. Amphibian skin secretions contain a plethora...
Antifungal effect of lactoferricin B like peptide derived from centipede
Antifungal effect and pore-forming action of lactoferricin B like peptide derived from centipede Scolopendra subspinipes mutilans. Choi H, Hwang JS, Lee DG. Biochim Biophys Acta. 2013, 1828, 2745-2750. doi: 10.1016/j.bbamem.2013.07.021. Epub 2013 Jul 26. The centipede...
Anticancer activities of an antimicrobial peptide derivative of Ixosin-B amide.
Anticancer activities of an antimicrobial peptide derivative of Ixosin-B amide. Hsiao YC, Wang KS, Tsai SH, Chao WT, Lung FD., Bioorg Med Chem Lett. 2013, 23, 5744-7. doi: 10.1016/j.bmcl.2013.07.063. Epub 2013 Aug 9. In nature, antimicrobial peptides (AMPs) represent...
Antifungal peptides from a novel bacterium isolated from honey.
Isolation and identification of antifungal peptides from Bacillus BH072, a novel bacterium isolated from honey. Zhao X, Zhou ZJ, Han Y, Wang ZZ, Fan J, Xiao HZ., Microbiol Res. 2013, 168, 598-606. doi: 10.1016/j.micres.2013.03.001. Epub 2013 Mar 30. A bacterial strain...
Cationic host defence peptides: potential as antiviral therapeutics.
Cationic host defense peptides: potential as antiviral therapeutics. Gwyer Findlay E, Currie SM, Davidson DJ., BioDrugs. 2013, 27, 479-93. doi: 10.1007/s40259-013-0039-0. There is a pressing need to develop new antiviral treatments; of the 60 drugs currently...
Mitochondrial-targeted peptide rapidly improves mitochondrial energetics and skeletal muscle performance in aged mice.
Mitochondrial-targeted peptide rapidly improves mitochondrial energetics and skeletal muscle performance in aged mice. Siegel MP, Kruse SE, Percival JM, Goh J, White CC, Hopkins HC, Kavanagh TJ, Szeto HH, Rabinovitch PS, Marcinek DJ., Aging Cell. 2013, 12, 763-71....
Preptin analogues: chemical synthesis, secondary structure and biological studies.
Preptin analogues: chemical synthesis, secondary structure and biological studies. Buchanan CM, Peng Z, Cefre A, Sarojini V., Chem Biol Drug Des. 2013, 82, 429-37. doi: 10.1111/cbdd.12168. Peptide hormones that modulate insulin secretion have been recognized to have...
