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Enantioselective Synthesis of 2-Substitued-Tetrahydroisoquinolin-1-yl Glycine Derivatives
Enantioselective Synthesis of 2-Substitued-Tetrahydroisoquinolin-1-yl Glycine Derivatives via Oxidative Cross-Dehydrogenative Coupling of Tertiary Amines and Chiral Nickel(II) Glycinate Shengbin Zhou , Jiang Wang , Daizong Lin , Fei Zhao , and Hong Liu J. Org. Chem.,...
Bis(2-sulfanylethyl)amido Peptides Enable Native Chemical Ligation at Proline
Bis(2-sulfanylethyl)amido Peptides Enable Native Chemical Ligation at Proline and Minimize Deletion Side-Product Formation Laurent Raibaut , Phillip Seeberger , and Oleg Melnyk * Org. Lett., Article ASAP DOI: 10.1021/ol402678a Publication Date (Web): October 11, 2013...
Effective synthesis of kynurenine-containing peptides
Effective synthesis of kynurenine-containing peptides via on-resin ozonolysis of tryptophan residues: synthesis of cyclomontanin B. Wong CT, Lam HY, Li X., Org Biomol Chem. 2013, 11, 7616-20. The preparation of Kyn-containing peptides is difficult, owing to the low...
Implications of Angiotensin II in Central Nervous System on Exercise Performance.
Implications of Angiotensin II in Central Nervous System on Exercise Performance. Leite LH, Santiago HP, de Almeida RS, Coimbra CC. Curr Protein Pept Sci. 2013 Oct 4. [Epub ahead of print] The renin-angiotensin system (RAS) consists of a complex enzyme-peptide system,...
A Novel Aliphatic Tachykinin from the Skin Secretion of the Chinese Brown Frog, Rana chensinensis.
Ranachensinin: A Novel Aliphatic Tachykinin from the Skin Secretion of the Chinese Brown Frog, Rana chensinensis. Wu Y, Li R, Ma J, Zhou M, Wang L, McClure TI, Cai J, Chen T, Shaw C. Protein Pept Lett. 2013, 20, 1217-1224. Amphibian skin secretions contain a plethora...
Antifungal effect of lactoferricin B like peptide derived from centipede
Antifungal effect and pore-forming action of lactoferricin B like peptide derived from centipede Scolopendra subspinipes mutilans. Choi H, Hwang JS, Lee DG. Biochim Biophys Acta. 2013, 1828, 2745-2750. doi: 10.1016/j.bbamem.2013.07.021. Epub 2013 Jul 26. The...
Anticancer activities of an antimicrobial peptide derivative of Ixosin-B amide.
Anticancer activities of an antimicrobial peptide derivative of Ixosin-B amide. Hsiao YC, Wang KS, Tsai SH, Chao WT, Lung FD., Bioorg Med Chem Lett. 2013, 23, 5744-7. doi: 10.1016/j.bmcl.2013.07.063. Epub 2013 Aug 9. In nature, antimicrobial peptides (AMPs) represent...
Antifungal peptides from a novel bacterium isolated from honey.
Isolation and identification of antifungal peptides from Bacillus BH072, a novel bacterium isolated from honey. Zhao X, Zhou ZJ, Han Y, Wang ZZ, Fan J, Xiao HZ., Microbiol Res. 2013, 168, 598-606. doi: 10.1016/j.micres.2013.03.001. Epub 2013 Mar 30. A bacterial...
Cationic host defence peptides: potential as antiviral therapeutics.
Cationic host defense peptides: potential as antiviral therapeutics. Gwyer Findlay E, Currie SM, Davidson DJ., BioDrugs. 2013, 27, 479-93. doi: 10.1007/s40259-013-0039-0. There is a pressing need to develop new antiviral treatments; of the 60 drugs currently...
Mitochondrial-targeted peptide rapidly improves mitochondrial energetics and skeletal muscle performance in aged mice.
Mitochondrial-targeted peptide rapidly improves mitochondrial energetics and skeletal muscle performance in aged mice. Siegel MP, Kruse SE, Percival JM, Goh J, White CC, Hopkins HC, Kavanagh TJ, Szeto HH, Rabinovitch PS, Marcinek DJ., Aging Cell. 2013, 12, 763-71....
Preptin analogues: chemical synthesis, secondary structure and biological studies.
Preptin analogues: chemical synthesis, secondary structure and biological studies. Buchanan CM, Peng Z, Cefre A, Sarojini V., Chem Biol Drug Des. 2013, 82, 429-37. doi: 10.1111/cbdd.12168. Peptide hormones that modulate insulin secretion have been recognized to have...
Protonectin, a Novel Antimicrobial Peptide from the Venom of the Neotropical Social Wasp Agelaia pallipes pallipes.
Membrane Perturbation Action Mode and Structure-Activity Relationships of Protonectin, a Novel Antimicrobial Peptide from the Venom of the Neotropical Social Wasp Agelaia pallipes pallipes. Wang K, Dang W, Yan J, Chen R, Liu X, Yan W, Zhang B, Xie J, Zhang J, Wang R....
Equine Antimicrobial Peptide eCATH1 Is Effective against Rhodococcus equi
The Equine Antimicrobial Peptide eCATH1 Is Effective against the Facultative Intracellular Pathogen Rhodococcus equi in Mice. Schlusselhuber M, Torelli R, Martini C, Leippe M, Cattoir V, Leclercq R, Laugier C, Grötzinger J, Sanguinetti M, Cauchard J. Antimicrob...
AGH is a new hemoglobin alpha-chain fragment with antinociceptive activity.
AGH is a new hemoglobin alpha-chain fragment with antinociceptive activity. Ribeiro NM, Toniolo EF, Castro LM, Russo LC, Rioli V, Ferro ES, Dale CS. Peptides. 2013, 48C, 10-20. doi: 10.1016/j.peptides.2013.07.011. Epub 2013 Aug 2. Limited proteolysis of certain...
GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding.
GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding. Gomes I, Aryal DK, Wardman JH, Gupta A, Gagnidze K, Rodriguiz RM, Kumar S, Wetsel WC, Pintar JE, Fricker LD, Devi LA. Proc Natl Acad Sci U S A. 2013, 110, 16211-16216....
Juvenile mouse pheromone peptide inhibits sexual behaviour
A juvenile mouse pheromone inhibits sexual behaviour through the vomeronasal system. Ferrero DM, Moeller LM, Osakada T, Horio N, Li Q, Roy DS, Cichy A, Spehr M, Touhara K, Liberles SD. Nature. 2013, Oct 2. doi: 10.1038/nature12579. [Epub ahead of print] Animals...
Cell penetration and cytosolic delivery of macromolecules by a telomerase-derived peptide vaccine.
Heat shock protein-mediated cell penetration and cytosolic delivery of macromolecules by a telomerase-derived peptide vaccine. Lee SA, Kim BR, Kim BK, Kim DW, Shon WJ, Lee NR, Inn KS, Kim BJ. Biomaterials. 2013, 34, 7495-505. doi: 10.1016/j.biomaterials.2013.06.015....
A mastoparan-derived peptide has broad-spectrum antiviral activity against enveloped viruses.
A mastoparan-derived peptide has broad-spectrum antiviral activity against enveloped viruses. Sample CJ, Hudak KE, Barefoot BE, Koci MD, Wanyonyi MS, Abraham S, Staats HF, Ramsburg EA. Peptides. 2013, 48C, 96-105. doi: 10.1016/j.peptides.2013.07.014. Epub 2013 Jul...
