Alkyne-Containing Amino Acids

Alkyne containing amino acids are useful building blocks for preparing modified peptides.  Utilizing Sonogashira coupling or 1,3-cycloaddition with azides, they can form cyclized structures, conjugate with labels or biomolecules, and form structurally diverse amino... Read more

Azide and Alkyne-Containing Amino Acids

Azide and alkyne containing amino acidsare useful building blocks for incorporating “click chemistry” into peptide synthesis.  The copper(I) catalyzed 1,3-dipolar cycloaddition of azides with alkynes to form 1,4-substituted 1,2,3-triazoles is a convenient method for... Read more

SARS CoV-2 Publications in September

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors Longxing Cao, Inna Goreshnik, Brian Coventry, James Brett Case, Lauren Miller, Lisa Kozodoy,Rita E. Chen, Lauren Carter, Alexandra C. Walls, Young-Jun Park, Eva-Maria Strauch, Lance Stewart, Michael S.... Read more

Peptide Libraries for Epitope Detection of Pathogens and Vaccine Development

Hess and Loeffler (K. Hess, et al., J. Proteome Res., 2020, Published Sept. 5, 2020) have published a review of how peptide libraries and microarrays can be utilized to rapidly detect immunogenic epitopes of pathogens.  These epitopes can be used to rapidly develop... Read more

SARS-CoV-2 Publications in July

Covid-19 continues to be a major health problem.   Research on the SARS-CoV-2 virus is continuing as potential vaccines are entering testing.  These are some of the publications from July concerning SARS-CoV-2. Adaptive Evolution of Peptide Inhibitors for Mutating... Read more

SARS CoV-2 Publications in June

Covid-19, caused by the SARS-CoV-2 virus, as yet does not have a proven vaccine or drug treatment to prevent infection.  Researchers globally are studying the virus and its method of infection to develop effective vaccines and drug treatments.  Listed below are a few... Read more

Peptides and Covid-19

Save 20% on the COVID-19 Research Products Listed Below through July 19. Click on the links to go directly to the products:   Fmoc-NH-PEG4-Propionic Acid [557756-85-1] Boc-NH-PEG6-COOH (30 atoms) [600141-83-1] Boc-NH-PEG3-Propionic Acid [1347750-75-7]... Read more

Beta-Amino Acids and beta-Homo Amino Acids

Beta-amino acids and beta-homo amino acids have related structures.  In both, the amino group is attached to the second carbon atom from the acid group.  The difference is in the carbon skeleton.  Beta-amino acids have the same carbon skeleton as alpha-amino acids,... Read more

Synthesizing Hydrophobic Peptides

Synthesizing hydrophobic peptides is often difficult.  Inter-chain hydrogen bonding in the hydrophobic regions causes poor solvation of the peptide chains and slowed reaction rates.  Measures to disrupt this hydrogen bonding often significantly improve the purity and... Read more

Hmb and Dmb Protected Derivatives

Fmoc-(Fmoc-Hmb)amino acids were introduced in the 1990s to improve synthetic yields of difficult peptides, such as amyloid β, that form aggregates during synthesis. It had been noted that tertiary amide bonds in a peptide sequence prevent interchain hydrogen bonding.... Read more

Fmoc-PEG Linkers and PEGylation Reagents

Modifying a peptide to include polyethylene glycol (PEG) groups may improve solubility and bioavailability. Protein PEGylation can protect the protein from proteolytic degradation and increase its half-life in biological applications, decrease its antigenisity or... Read more

Pseudoproline Dipeptides

Pseudoproline dipeptides contain oxazoles formed from serine or threonine. When treated with trifluoroacetic acid (TFA), the oxazoles are converted to serine or threonine. The oxazoles have structural similarities to proline, thus they are named pseudoprolines. Like... Read more