SARS-CoV-2 Publications in July

Covid-19 continues to be a major health problem.   Research on the SARS-CoV-2 virus is continuing as potential vaccines are entering testing.  These are some of the publications from July concerning SARS-CoV-2. Adaptive Evolution of Peptide Inhibitors for Mutating... Read more

SARS CoV-2 Publications in June

Covid-19, caused by the SARS-CoV-2 virus, as yet does not have a proven vaccine or drug treatment to prevent infection.  Researchers globally are studying the virus and its method of infection to develop effective vaccines and drug treatments.  Listed below are a few... Read more

Peptides and Covid-19

Save 20% on the COVID-19 Research Products Listed Below through July 19. Click on the links to go directly to the products:   Fmoc-NH-PEG4-Propionic Acid [557756-85-1] Boc-NH-PEG6-COOH (30 atoms) [600141-83-1] Boc-NH-PEG3-Propionic Acid [1347750-75-7]... Read more

Beta-Amino Acids and beta-Homo Amino Acids

Beta-amino acids and beta-homo amino acids have related structures.  In both, the amino group is attached to the second carbon atom from the acid group.  The difference is in the carbon skeleton.  Beta-amino acids have the same carbon skeleton as alpha-amino acids,... Read more

Synthesizing Hydrophobic Peptides

Synthesizing hydrophobic peptides is often difficult.  Inter-chain hydrogen bonding in the hydrophobic regions causes poor solvation of the peptide chains and slowed reaction rates.  Measures to disrupt this hydrogen bonding often significantly improve the purity and... Read more

Hmb and Dmb Protected Derivatives

Fmoc-(Fmoc-Hmb)amino acids were introduced in the 1990s to improve synthetic yields of difficult peptides, such as amyloid β, that form aggregates during synthesis. It had been noted that tertiary amide bonds in a peptide sequence prevent interchain hydrogen bonding.... Read more

Fmoc-PEG Linkers and PEGylation Reagents

Modifying a peptide to include polyethylene glycol (PEG) groups may improve solubility and bioavailability. Protein PEGylation can protect the protein from proteolytic degradation and increase its half-life in biological applications, decrease its antigenisity or... Read more

Pseudoproline Dipeptides

Pseudoproline dipeptides contain oxazoles formed from serine or threonine. When treated with trifluoroacetic acid (TFA), the oxazoles are converted to serine or threonine. The oxazoles have structural similarities to proline, thus they are named pseudoprolines. Like... Read more

High Performance Peptide Synthesizers

High performance solid phase peptide synthesis of long or difficult peptides may require the utilization of special coupling reagents for specific residues within the peptide sequence. The Focus XC Series of high performance peptide synthesizers have the capacity and... Read more

PACAP-38 has a protective effect in diabetic retinopathy.

Diabetic retinopathy is the leading cause of blindness in people aged between 20 and 60 years. After 15 years of having diabetes, 98 percent of patients with Type 1 diabetes and 78 percent of patients with Type 2 diabetes have some degree of retinal damage. A recent... Read more

Isoacyl Dipeptides

Isoacyl Dipeptides Isoacyl dipeptides are used to prepare depsipeptides in which the peptide chain is attached to the side chain oxygen atom of serine or threonine residues instead of the alpha nitrogen. Depsipeptides are less prone to aggregation than their standard... Read more