Hmb and Dmb Protected Derivatives

Fmoc-(Fmoc-Hmb)amino acids were introduced in the 1990s to improve synthetic yields of difficult peptides, such as amyloid β, that form aggregates during synthesis. It had been noted that tertiary amide bonds in a peptide sequence prevent interchain hydrogen bonding.... Read more

PEG Linkers and PEGylation Reagents

Modifying a peptide to include polyethylene glycol (PEG) groups may improve solubility and bioavailability. Protein PEGylation can protect the protein from proteolytic degradation and increase its half-life in biological applications, decrease its antigenisity or... Read more

Pseudoproline Dipeptides

Pseudoproline dipeptides contain oxazoles formed from serine or threonine. When treated with trifluoroacetic acid (TFA), the oxazoles are converted to serine or threonine. The oxazoles have structural similarities to proline, thus they are named pseudoprolines. Like... Read more

High Performance Peptide Synthesizers

High performance solid phase peptide synthesis of long or difficult peptides may require the utilization of special coupling reagents for specific residues within the peptide sequence. The Focus XC Series of high performance peptide synthesizers have the capacity and... Read more

PACAP-38 has a protective effect in diabetic retinopathy.

Diabetic retinopathy is the leading cause of blindness in people aged between 20 and 60 years. After 15 years of having diabetes, 98 percent of patients with Type 1 diabetes and 78 percent of patients with Type 2 diabetes have some degree of retinal damage. A recent... Read more

Isoacyl Dipeptides

Isoacyl Dipeptides Isoacyl dipeptides are used to prepare desipeptides in which the peptide chain is attached to the side chain oxygen atom of serine or threonine residues instead of the alpha nitrogen. Depsipeptides are less prone to aggregation than their standard... Read more