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Neuromedin B is essential for signaling sneezing

In a paper published in Cell, researchers have shown that the peptide neuromedin B (NMB) is essential for signaling sneezing.  Mice deficient in NMB recptors and mice with NMB-sensitive neurons ablated in the sneeze-evoking region did not show the sneeze reflex.... Read more

Carbodiimides and Additives

Carbodiimides Carbodimides were some of the first coupling reagents used in solid phase peptide synthesis and are still used in many instances.  Although carbodiimides might not couple as rapidly as newer coupling reagents, they still have advantages in certain... Read more

SARS-CoV-2 Selected Papers November-December 2020

Vaccines against the SARS-CoV-2 virus are just becoming available. While this is good news for controlling the spread of the virus, there has not been as much success in developing therapeutic agents for treating patients infected with SARS-CoV-2.  A significant... Read more

Alkyne-Containing Amino Acids

Alkyne containing amino acids are useful building blocks for preparing modified peptides.  Utilizing Sonogashira coupling or 1,3-cycloaddition with azides, they can form cyclized structures, conjugate with labels or biomolecules, and form structurally diverse amino... Read more

Azide and Alkyne-Containing Amino Acids

Azide and alkyne containing amino acids are useful building blocks for incorporating “click chemistry” into peptide synthesis.  The copper(I) catalyzed 1,3-dipolar cycloaddition of azides with alkynes to form 1,4-substituted 1,2,3-triazoles is a convenient method for... Read more

SARS CoV-2 Publications in September

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors Longxing Cao, Inna Goreshnik, Brian Coventry, James Brett Case, Lauren Miller, Lisa Kozodoy,Rita E. Chen, Lauren Carter, Alexandra C. Walls, Young-Jun Park, Eva-Maria Strauch, Lance Stewart, Michael S.... Read more

SARS-CoV-2 Publications in July

Covid-19 continues to be a major health problem.   Research on the SARS-CoV-2 virus is continuing as potential vaccines are entering testing.  These are some of the publications from July concerning SARS-CoV-2. Adaptive Evolution of Peptide Inhibitors for Mutating... Read more

SARS CoV-2 Publications in June

Covid-19, caused by the SARS-CoV-2 virus, as yet does not have a proven vaccine or drug treatment to prevent infection.  Researchers globally are studying the virus and its method of infection to develop effective vaccines and drug treatments.  Listed below are a few... Read more

Peptides and Covid-19

Save 20% on the COVID-19 Research Products Listed Below through July 19. Click on the links to go directly to the products:   Fmoc-NH-PEG4-Propionic Acid [557756-85-1] Boc-NH-PEG6-COOH (30 atoms) [600141-83-1] Boc-NH-PEG3-Propionic Acid [1347750-75-7]... Read more

Beta-Amino Acids and beta-Homo Amino Acids

Beta-amino acids and beta-homo amino acids have related structures.  In both, the amino group is attached to the second carbon atom from the acid group.  The difference is in the carbon skeleton.  Beta-amino acids have the same carbon skeleton as alpha-amino acids,... Read more

Synthesizing Hydrophobic Peptides

Synthesizing hydrophobic peptides is often difficult.  Inter-chain hydrogen bonding in the hydrophobic regions causes poor solvation of the peptide chains and slowed reaction rates.  Measures to disrupt this hydrogen bonding often significantly improve the purity and... Read more