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Synthesis and Use of Fmoc-Lys(5-Fam)-OH

The synthesis and application of Fmoc-Lys(5-Fam) building blocks. Tokmina-Roszyk M, Tokmina-Roszyk D, Fields GB. Biopolymers. 2013 Feb 26. doi: 10.1002/bip.22222. [Epub ahead of print] Fluorescence resonance energy transfer (FRET) peptide substrates are often utilized... Read more

Preparation of C-terminal Peptide Thiolesters

A comparison of Boc and Fmoc SPPS strategies for the preparation of C-terminal peptide α-thiolesters: NY-ESO-1 (39) Cys-(68) Ala-COSR. Harris PW, Brimble MA., Biopolymers. 2013 Feb 26. doi: 10.1002/bip.22223. [Epub ahead of print] The synthesis of a polypeptide... Read more

Alanine Scan of Peptide Antibiotic Feglymycin

Alanine Scan of the Peptide Antibiotic Feglymycin: Assessment of Amino Acid Side Chains Contributing to Antimicrobial Activity. Hänchen A, Rausch S, Landmann B, Toti L, Nusser A, Süssmuth RD. Chembiochem., 2013, 14, 625-32. DOI: 10.1002/cbic.201300032. The... Read more

New Arginine Vasopressin Analogs

Design, Synthesis and Structure–Activity Relationship of New Arginine Vasopressin Analogues Containing Proline Derivatives in Position 2 A Kwiatkowska, M Lewandowska, L Borovičková, J Slaninová, B Lammek, A Prahl, Chem. Biol. Drug Design, 2013, 81, 420–428.... Read more

Boc-Oxyma as Racemization-Free Coupling Reagent

Ethyl 2-(tert-Butoxycarbonyloxyimino)-2-cyanoacetate (Boc-Oxyma) as Coupling Reagent for Racemization-Free Esterification, Thioesterification, Amidation and Peptide Synthesis K Thalluri, KC Nadimpally, MP Chakravarty, A Paul, B Mandal, Advan. Synth. Catal., 2013, 355,... Read more