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Apex 396 Parallel Synthesizer

The Apex 396 Automated Multiple Peptide Synthesizer is the established market leader in parallel peptide synthesizers and single peptide synthesizers. This peptide instrument is ideal for producing drug discovery libraries, alanine scans, epitope mapping and peptide parallel libraries. Synthesis scales range from 1 mg up to 20 grams.

Peptides, Peptoids and More

Due to the flexibility designed into the Apex 396, it can be utilized in a broad variety of resin-supported chemistry.  Peptoid synthesis by the submonomer method is quite successful on the Apex 396. [Click for references of peptoid synthesis on the Apex] The small scale capability of the Apex 396 plus its ability to deliver monomers and reagents with syringe-like accuracy make the Apex ideal for PNA synthesis. [Click for references of PNA synthesis on the Apex] [Click for the Apex 396 PNA Synthesis Technical Bulletin]

Higher Yields

Due to the unique design of the Teflon reactor assembly, the resin stays at the bottom of the reactor, allowing it to stay in full contact with the reaction solution. Because of this, the resin does not stick to the sides of the reactor, thus the Apex 396 parallel peptide synthesizer produces higher yields of complete peptides with fewer deletion impurities.

Applying heat during difficult couplings often accelerates the reaction and improves the reaction yield. Heating and cooling options are available on the Apex 396, allowing chemists to optimize temperature during each coupling for maximum yield.


The nitrogen-assisted bottom filtration quickly and thoroughly empties the reactor while maintaining an inert atmosphere, resulting in quick emptying. This process, in combination with fast delivery, minimizes the decomposition of the peptide resin due to extended contact with acid or base and allows quick, thorough and efficient washing of the resin to prevent impurities due to carryover.


These features make the Apex 396 Automated Multiple Peptide Synthesizer the obvious choice for automated ambient temperature parallel synthesis of peptides.

For more about the Apex 396 Automated Multiple Peptide Synthesizer send an e-mail to