You are here: Home » Resources » Solid Phase Peptide Synthesis » Amino Acid Derivatives for Peptide Synthesis » Amino Acid Properties

Amino Acid Properties

 

Type Acidic Basic
Amino Acid Aspartic Acid Glutamic Acid Histidine Arginine Lysine
Structure
Three Letter Code Asp Glu His Arg Lys
One Letter Code D E H R K
Molecular Formula C4H7NO4 C5H9NO4 C6H9N3O2 C6H14N4O2 C6H14N2O2
Molecular Weight 133.1147.1 155.2174.2 146.2
Residue Formula C4H5NO3 C5H7NO3 C6H7N3O C6H12N4O C6H12N2O
Residue Weight 115.1 129.1 137.1156.2 128.2
pI at 25 C(Isoelectric Point) 2.983.08 7.64 10.76 9.47
Hydrophobicity LowLowModerate Very LowVery Low
alpha-Helix Forming ModerateStrongModerateModerateModerate
beta-Sheet FormingWeakWeakWeakModerateWeak
Turn FormingStrongWeakModerateModerateModerate

 

Type Polar
Amino AcidCysteineAsparagineGlutamineSerineThreonine
Structure
Three Letter CodeCysAsnGlnSerThr
One Letter CodeCNQST
Molecular FormulaC3H7NO2SC4H8N2O3C5H10N2O3C3H7NO3C4H9NO3
Molecular Weight121.2132.1146.1105.1119.1
Residue FormulaC3H5NOSC4H6N2O2C5H8N2O2C3H5NO2C4H7NO2
Residue Weight103.1114.1128.187.1101.1
pI at 25 C (Isoelectric Point)5.022.775.655.685.64
HydrophobicityHighLowLowModerateModerate
alpha-Helix FormingWeakWeakModerateWeakWeak
beta-Sheet FormingModerateModerateModerateWeakModerate
Turn FormingModerateStrongModerateStrongModerate

 

TypeAromaticAliphatic
Amino AcidPhenylalanineTyrosineTryptophanGlycineAlanine
Structure
Three Letter CodePheTyrTrpGlyAla
One Letter CodeFYWGA
Molecular FormulaC9H11NO2C9H11NO3C11H12N2O2C2H5NO2C3H7NO2
Molecular Weight165.2181.2204.275.189.1
Residue FormulaC9H9NOC9H9NO2C11H10N2OC2H3NOC3H5NO
Residue Weight147.2163.2186.257.171.1
pI at 25 C (Isoelectric Point)5.91 5.635.886.0646.107
HydrophobicityVery HighModerateHighHighHigh
alpha-Helix FormingModerateWeakModerateWeakStrong
beta-Sheet Forming StrongStrongStrong WeakWeak
Turn Forming WeakModerateModerate StrongWeak

 

Type Aliphatic    
Amino AcidValine Leucine IsoleucineMethionine Proline
Structure
Three Letter Code Val Leu Ile Met Pro
One Letter Code VL IM P
Molecular Formula C5H11NO2 C6H13NO2 C6H13NO2 C5H11NO2S C5H9NO2
Molecular Weight 117.7131.2 131.2149.2 115.1
Residue Formula C5H9NOC6H11NOC6H11NOC5H9NOSC5H7NO
Residue Weight99.1113.2113.2131.297.1
pI at 25 C (Isoelectric Point)6.0026.0366.0385.746.3
HydrophobicityVery HighVery HighVery HighHighModerate
alpha-Helix FormingModerateStrongModerateStrongWeak
beta-Sheet FormingStrongStrongStrongModerateWeak
Turn FormingWeakWeakWeakWeakStrong