In a paper published in Cell, researchers have shown that the peptide neuromedin B (NMB) is essential for signaling sneezing. Mice deficient in NMB recptors and mice with NMB-sensitive neurons ablated in the sneeze-evoking region did not show the sneeze reflex. Chemically activating NMB-sensitive neurons led to sneezing.
Earlier, neuromedin B was shown to induce acute itch in mice and monkeys. It induced itching by activating the peripheral sensory neurons. Unlike gastrin-releasing peptide (GRP), which also induces itch, NMB does not involve mast cell degranulation.
AAPPTec offers high quatity Neuromedin B peptides for researchers world-wide. Order on-line or contact AAPPTec to place an order.
