Hess and Loeffler (K. Hess, et al., J. Proteome Res., 2020, Published Sept. 5, 2020) have published a review of how peptide libraries and microarrays can be utilized to rapidly detect immunogenic epitopes of pathogens. These epitopes can be used to rapidly develop diagnostic tests and vaccines, both which are essential in controlling pandemics. This review is especially relevant due to the current Covid-19 epidemic.
In general, libraries of overlapping peptides generated from the sequence of surface proteins of viruses or microbes are scanned with antibodes from infected patients. The peptides that bind antibodies more strongly become leads for developing diagnostic tests or vaccines (L Farrera-Soler, et al., PLoS One, 2020, 15(9), e0238089).
AAPPTec excels in producing custom peptide libraries for epitope mapping, binding studies, or structure-activity studies. We have developed the instrumentation and synthesis protocols to produce peptide libraries in high quality and high-throughput.