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Postsynthetic Modification of Unprotected Peptides via S-Tritylation Reaction Mochizuki M, Hibino H, Nishiuchi Y, Org. Lett.2014 Articles ASAP (As Soon As Publishable)

Tritylation using trityl alcohol (Trt–OH) in 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) is a convenient and efficient procedure that can offer S-protection of the Cys located in fully unprotected peptides. The procedure simply requires Trt–OH and HFIP to selectively promote S-tritylation in the presence of peptide nucleophilic functionalities.