CY Pan,Â JC Chen,Â JF Sheen,Â TL Lin,Â JY Chen, AntimicrobÂ AgentsÂ Chemother.Â , 2014 May 12. [Epub ahead of print]
AntimicrobialÂ peptidesÂ (AMPs) are garnering attention as possible alternatives to antibiotics. Here, we describe theÂ antimicrobialÂ properties of epinecidin-1 against multi-drug resistant clinical isolates of P. aeruginosa (P. aeruginosa (R)) and P. aeruginosa from ATCC (P. aeruginosa (19660)) in vivo. The minimum inhibitory concentrations (MICs) of epinecidin-1 against P. aeruginosa (R) and P. aeruginosa (19660) were determined, and compared with those of imipenem. Epinecidin-1 was found to be highly effective at combating peritonitis infection caused by P. aeruginosa (R) or P. aeruginosa (19660) in mouse models, without inducing adverse behavioral effects, or liver or kidney toxicity. Taken together, our results indicate that epinecidin-1 enhances the survival rate of mice infected with the bacterial pathogen P. aeruginosa through bothÂ antimicrobialÂ and immunomodulatory effects.