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Minimum active structure of insulin-like peptide 5 (INSL5)
Alessia Belgi , Ross A.D. Bathgate , Martina Kocan , Nitin Patil , Suode Zhang , Geoffrey W Tregear , John D. Wade , and Mohammed Akhter Hossain, J. Med. Chem., Just Accepted Manuscript
DOI: 10.1021/jm400924p
Publication Date (Web): November 4, 2013
Copyright © 2013 American Chemical Society

Insulin-like peptide 5 (INSL5) is a complex two-chain peptide hormone constrained by three disulfide bonds in a pattern identical to insulin. High expression of INSL5 in the colon suggests roles in activation of colon motility and appetite control. A more recent study indicates it may have significant roles in the regulation of insulin secretion and β-cell homeostasis. This peptide thus has considerable potential for the treatment of eating disorders, obesity and/or diabetes. However, the synthesis of INSL5 is extremely challenging either by chemical or recombinant means. The A-chain is very poorly soluble and the B-chain is highly aggregating in nature which, together, makes their post-synthesis handling and purification very difficult. Given these difficulties, we have developed a highly active INSL5 analogue that has a much simpler structure with two disulfide bonds and thus easier to assemble compared to native INSL5. This minimized peptide represents an attractive new mimetic for investigating the functional role of INSL5.