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Soluble and Reusable Poly(norbornene) Supports with High Loading Capacities for Peptide Synthesis
Nimmashetti Naganna and Nandita Madhavan *
Org. Lett., 2013, 15, 5870-5873.
DOI: 10.1021/ol4029435
Copyright © 2013 American Chemical Society

Poly(norbornene) supports comprising solubilizing ethylene glycol units and multiple amino acid attachment sites have been developed for peptide synthesis. A variety of amino acids have been efficiently loaded (0.6–1.1 mmol/g) onto the support in high yields (83–98%). Several tripeptides have been synthesized in moderate-to-good overall yields (41–66%) using only 1.2 equiv of coupling reagents/amino acids, and the support could be efficiently recycled up to 3 times.