Soluble and Reusable Poly(norbornene) Supports with High Loading Capacities for Peptide Synthesis
Nimmashetti Naganna and Nandita Madhavan *
Org. Lett., 2013, 15, 5870-5873.
Copyright © 2013 American Chemical Society
Poly(norbornene) supports comprising solubilizing ethylene glycol units and multiple amino acid attachment sites have been developed for peptide synthesis. A variety of amino acids have been efficiently loaded (0.6â€“1.1 mmol/g) onto the support in high yields (83â€“98%). Several tripeptides have been synthesized in moderate-to-good overall yields (41â€“66%) using only 1.2 equiv of coupling reagents/amino acids, and the support could be efficiently recycled up to 3 times.