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Prospects in the Total Synthesis of Protein Therapeutics
Justin M. Chalker
Chem. Biol. Drug Design, 2013, 81, 122–135
DOI: 10.1111/cbdd.12007

Protein therapeutics are gaining headway in the treatment and prevention of a variety of maladies. Critical to the success and growing use of biologic-level pharmaceuticals is the development of methods for their precise synthesis. This review highlights the emerging techniques for the total synthesis of proteins, with a special focus on the possibility of accessing therapeutic targets through chemoselective peptide ligations.