Synthesis and Catalytic Activity of Amino Acids and Metallopeptides with Catalytically Active Metallocyclic Side Chains
Zhihui Zhong , Hao Yang , Chen Zhang , and Jared C. Lewis
Organometallics, Article ASAP
DOI: 10.1021/om300848p
Publication Date (Web): October 18, 2012
Copyright © 2012 American Chemical Society
Two approaches to prepare amino acids with catalytically active organometallic side chains are presented. These methods are notable in that they provide access either free or N-protected compounds that are structurally analogous to naturally occurring amino acids. The N-protected organometallic amino acids are compatible with standard peptide coupling conditions and can be used to prepare catalytically active metallopeptides.
