Machado, et al. recently published a paper (J. Pept. Sci. 2012, 18, 588-98) in which they report synthesized backbone cyclized analogs of gomesin, an antimicrobial peptide from the hemocytes of the Brazilian spider Acantoscurria gomesiana. They performed the backbone cyclization on resin using 20% DMSO/NMP and EDC/HOBt. Conventional heating at 60 degrees C appeared to be particularly suitable for the backbone cyclization. This is one more example of how heating during peptide synthesis can have beneficial effects.