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Home » Synthesis of cyclic gomesin

Machado, et al. recently published a paper (J. Pept. Sci. 2012, 18, 588-98) in which they report synthesized backbone cyclized analogs of gomesin, an antimicrobial peptide from the hemocytes of the Brazilian spider Acantoscurria gomesiana.  They performed the backbone cyclization on resin using 20% DMSO/NMP and EDC/HOBt.   Conventional heating at 60 degrees C appeared to be particularly suitable for the backbone cyclization.  This is one more example of how heating during peptide synthesis can have beneficial effects.